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Journal of Bacteriology, July 2005, p. 5036-5039, Vol. 187, No. 14
0021-9193/05/$08.00+0     doi:10.1128/JB.187.14.5036-5039.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Identification of nlmTE, the Locus Encoding the ABC Transport System Required for Export of Nonlantibiotic Mutacins in Streptococcus mutans

John D. F. Hale, Nicholas C. K. Heng,* Ralph W. Jack, and John R. Tagg

Department of Microbiology and Immunology, University of Otago, P.O. Box 56, Dunedin, New Zealand

Received 17 December 2004/ Accepted 18 April 2005

Streptococcus mutans UA159, the genome sequence reference strain, exhibits nonlantibiotic bacteriocin (mutacin) activity. In this study, we have combined bioinformatic and mutational analyses to identify the ABC transporter designated NlmTE, which is required for mutacin biogenesis in strain UA159 as well as in another mutacin producer, S. mutans N.


* Corresponding author. Mailing address: Department of Microbiology and Immunology, University of Otago, P.O. Box 56, Dunedin, New Zealand. Phone: 64 3 479-5155. Fax: 64 3 479-8540. E-mail: nicholas.heng{at}stonebow.otago.ac.nz.


Journal of Bacteriology, July 2005, p. 5036-5039, Vol. 187, No. 14
0021-9193/05/$08.00+0     doi:10.1128/JB.187.14.5036-5039.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.




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