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Journal of Bacteriology, August 2005, p. 5486-5492, Vol. 187, No. 15
0021-9193/05/$08.00+0     doi:10.1128/JB.187.15.5486-5492.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Global Regulation of Gene Expression by ArlRS, a Two-Component Signal Transduction Regulatory System of Staphylococcus aureus

Xudong Liang,1 Li Zheng,1 Christina Landwehr,1 Dwayne Lunsford,2 David Holmes,2 and Yinduo Ji1*

Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Ave., St. Paul, Minnesota 55108,1 Anti-Infective Research, GlaxoSmithKline Research and Development, 1250 S. Collegeville Rd., Collegeville, Pennsylvania 194262

Received 3 March 2005/ Accepted 26 April 2005

Staphylococcus aureus expresses various cell wall-associated and extracellular virulence factors, coordinately controlled by different two-component signal transduction systems and transcriptional regulators. In this study, we used microarray technology to identify the genes regulated by ArlR. The microarray data indicate that ArlR functions as a positive regulator and also as a negative repressor to directly and/or indirectly mediate the expression of at least 114 genes involved in different functions, including autolysis, cell division, growth, and pathogenesis.

* Corresponding author. Mailing address: Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Ave., St. Paul, MN 55108. Phone: (612) 624-2757. Fax: (612) 625-5203. E-mail: jixxx002{at}umn.edu.

Journal of Bacteriology, August 2005, p. 5486-5492, Vol. 187, No. 15
0021-9193/05/$08.00+0     doi:10.1128/JB.187.15.5486-5492.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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