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 Previous Article

Journal of Bacteriology, August 2005, p. 5857-5860, Vol. 187, No. 16
0021-9193/05/$08.00+0     doi:10.1128/JB.187.16.5857-5860.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

The Large First Periplasmic Loop of SecD and SecF Plays an Important Role in SecDF Functioning

Nico Nouwen,* Magdalena Piwowarek, Greetje Berrelkamp, and Arnold J. M. Driessen

Department of Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands

Received 4 April 2005/ Accepted 27 May 2005

A remarkable feature of proteins of the SecD and SecF family involved in protein translocation is that they possess a very large first periplasmic domain. Here we report that this large first periplasmic domain is not required for the SecD-SecF interaction but that it is important for catalyzing protein translocation.

* Corresponding author. Mailing address: Department of Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands. Phone: 31-60-3632403. Fax: 31-50-3632154. E-mail: n.p.nouwen{at}rug.nl.

Journal of Bacteriology, August 2005, p. 5857-5860, Vol. 187, No. 16
0021-9193/05/$08.00+0     doi:10.1128/JB.187.16.5857-5860.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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  • Sibbald, M. J. J. B., Ziebandt, A. K., Engelmann, S., Hecker, M., de Jong, A., Harmsen, H. J. M., Raangs, G. C., Stokroos, I., Arends, J. P., Dubois, J. Y. F., van Dijl, J. M. (2006). Mapping the Pathways to Staphylococcal Pathogenesis by Comparative Secretomics. Microbiol. Mol. Biol. Rev. 70: 755-788 [Abstract] [Full Text]  
  • Hand, N. J., Klein, R., Laskewitz, A., Pohlschroder, M. (2006). Archaeal and Bacterial SecD and SecF Homologs Exhibit Striking Structural and Functional Conservation. J. Bacteriol. 188: 1251-1259 [Abstract] [Full Text]  
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