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Journal of Bacteriology, October 2005, p. 6852-6855, Vol. 187, No. 19
0021-9193/05/$08.00+0     doi:10.1128/JB.187.19.6852-6855.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Inactivation of Protein Translocation by Cold-Sensitive Mutations in the yajC-secDF Operon

Nico Nouwen* and Arnold J. M. Driessen

Department of Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands

Received 28 April 2005/ Accepted 25 July 2005

Most mutations in the yajC-secDF operon identified via genetic screens confer a cold-sensitive growth phenotype. Here we report that two of these mutations confer this cold-sensitive phenotype by inactivating the SecDF-YajC complex in protein translocation.

* Corresponding author. Mailing address: Department of Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands. Phone: 31-60-3632403. Fax: 31-50-3632154. E-mail: n.p.nouwen{at}rug.nl.

Journal of Bacteriology, October 2005, p. 6852-6855, Vol. 187, No. 19
0021-9193/05/$08.00+0     doi:10.1128/JB.187.19.6852-6855.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Hand, N. J., Klein, R., Laskewitz, A., Pohlschroder, M. (2006). Archaeal and Bacterial SecD and SecF Homologs Exhibit Striking Structural and Functional Conservation. J. Bacteriol. 188: 1251-1259 [Abstract] [Full Text]  


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