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Journal of Bacteriology, December 2005, p. 8191-8195, Vol. 187, No. 23
0021-9193/05/$08.00+0     doi:10.1128/JB.187.23.8191-8195.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Four Unusual Two-Component Signal Transduction Homologs, RedC to RedF, Are Necessary for Timely Development in Myxococcus xanthus

Penelope I. Higgs,^1, Kyungyun Cho,² David E. Whitworth,³ Lisa S. Evans,³ and David R. Zusman^1*

Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3204,¹ Section of Life Science, Hoseo University, Asan 336-795, Korea,² Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom³

Received 27 May 2005/ Accepted 14 September 2005

We identified a cluster of four two-component signal transduction genes that are necessary for proper progression of Myxococcus xanthus through development. redC to redF mutants developed and sporulated early, resulting in small, numerous, and disorganized fruiting bodies. Yeast two-hybrid analyses suggest that RedCDEF act in a single signaling pathway. The previously identified espA gene displays a phenotype similar to that of redCDEF. However, combined mutants defective in espA redCDEF exhibited a striking additive developmental phenotype, suggesting that EspA and RedC to RedF play independent roles in controlling developmental progression.

Present address: Max Planck Institute for Terrestrial Microbiology, Karl-von-Frisch Str., 35043 Marburg, Germany.

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