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Journal of Bacteriology, December 2005, p. 8494-8498, Vol. 187, No. 24
0021-9193/05/$08.00+0     doi:10.1128/JB.187.24.8494-8498.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

The Shiga Toxin 1-Converting Bacteriophage BP-4795 Encodes an NleA-Like Type III Effector Protein

Kristina Creuzburg,1,{dagger} Jürgen Recktenwald,2,§ Volker Kuhle,3 Sylvia Herold,1,{dagger} Michael Hensel,3 and Herbert Schmidt4*

Institute of Medical Microbiology and Hygiene, Technical University of Dresden, 01307 Dresden, Germany,1 Institute of Hygiene and Microbiology, University of Würzburg, 97070 Würzburg, Germany,2 Institute of Clinical Microbiology, Immunology and Hygiene, FAU Erlangen-Nürnberg, 91054 Erlangen, Germany,3 Institute of Food Technology, Department of Food Microbiology, University of Hohenheim, 70599 Stuttgart, Germany4

Received 6 July 2005/ Accepted 21 September 2005

In this study, the complete DNA sequence of Shiga toxin 1-converting bacteriophage BP-4795 was determined. The genome of BP-4795 consists of 85 open reading frames, including two complete IS629 elements and three morons at the end of its late regulatory region. One of these morons encodes a type III effector that is translocated by the locus of enterocyte effacement-encoded type III secretion system into HeLa cells, where it localizes with the Golgi apparatus.

* Corresponding author. Mailing address: Department of Food Microbiology, Institute of Food Technology, University of Hohenheim, Garbenstrasse 28, 70599 Stuttgart, Germany. Phone: 49-711/459-2305. Fax: 49-711/459-4199. E-mail: hschmidt{at}uni-hohenheim.de.

{dagger} Present address: Institute of Food Technology, Department of Food Microbiology, University of Hohenheim, 70599 Stuttgart, Germany.

§ Present address: Phenion GmbH & CoKG, 60439 Frankfurt, Germany.

Journal of Bacteriology, December 2005, p. 8494-8498, Vol. 187, No. 24
0021-9193/05/$08.00+0     doi:10.1128/JB.187.24.8494-8498.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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