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Journal of Bacteriology, December 2005, p. 8531-8536, Vol. 187, No. 24
0021-9193/05/$08.00+0     doi:10.1128/JB.187.24.8531-8536.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Characterization of the DNA Gyrase from the Thermoacidophilic Archaeon Thermoplasma acidophilum

Kan Yamashiro and Akihiko Yamagishi*

Department of Molecular Biology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan

Received 28 May 2005/ Accepted 2 October 2005

Thermoplasma acidophilum is sensitive to the antibiotic drug novobiocin, which inhibits DNA gyrase. We characterized DNA gyrases from T. acidophilum strains in vitro. The DNA gyrase from a novobiocin-resistant strain and an engineered mutant were less sensitive to novobiocin. The novobiocin-resistant gyrase genes might serve as T. acidophilum genetic markers.

* Corresponding author. Mailing address: Department of Molecular Biology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392 Japan. Phone: 81-426-76-7139. Fax: 81-426-76-7145. E-mail: yamagish{at}ls.toyaku.ac.jp.

Journal of Bacteriology, December 2005, p. 8531-8536, Vol. 187, No. 24
0021-9193/05/$08.00+0     doi:10.1128/JB.187.24.8531-8536.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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