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Journal of Bacteriology, February 2005, p. 1196-1200, Vol. 187, No. 3
0021-9193/05/$08.00+0     doi:10.1128/JB.187.3.1196-1200.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

DNA Methylation in Lysogens of Pathogenic Burkholderia spp. Requires Prophage Induction and Is Restricted to Excised Phage DNA

M. J. Smith1 and J. A. Jeddeloh1,2*

Orion Genomics, St. Louis, Missouri,1 Bacteriology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland2

Received 3 May 2004/ Accepted 18 October 2004

Burkholderia mallei-specific phage {Phi}E125 encodes DNA methyltransferases in both the lysogenic and replication modules within its genome. Characterization of DNA methylation in recombinant systems, specifically in {Phi}E125 lysogenic strains of B. mallei and Burkholderia thailandensis, revealed that, upon induction, cytosine methylation was targeted specifically to the phage episome but not the phage provirus or the host chromosome.

* Corresponding author. Present address: Orion Genomics, 4041 Forest Park, St. Louis, MO 63108. Phone: (314) 615-6382. Fax: (314) 615-6975. E-mail: jjeddeloh{at}oriongenomics.com.

Journal of Bacteriology, February 2005, p. 1196-1200, Vol. 187, No. 3
0021-9193/05/$08.00+0     doi:10.1128/JB.187.3.1196-1200.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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