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Journal of Bacteriology, March 2005, p. 2200-2202, Vol. 187, No. 6
0021-9193/05/$08.00+0     doi:10.1128/JB.187.6.2200-2202.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

A Mutation in the Decoding Center of Thermus thermophilus 16S rRNA Suggests a Novel Mechanism of Streptomycin Resistance

Steven T. Gregory, Jennifer F. Carr, and Albert E. Dahlberg*

Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island

Received 11 October 2004/ Accepted 1 December 2004

A spontaneous kanamycin resistance and capreomycin resistance mutation, A1408G, in the decoding center of 16S rRNA, was identified in the extreme thermophile Thermus thermophilus. Unexpectedly, this mutation also confers resistance to streptomycin. We propose a novel mechanism of streptomycin resistance by which A1408G influences conformational changes in 16S rRNA during tRNA selection.

* Corresponding author. Mailing address: Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912. Phone: (401) 863-2223. Fax: (401) 863-1182. E-mail: Albert_Dahlberg{at}Brown.edu.

Journal of Bacteriology, March 2005, p. 2200-2202, Vol. 187, No. 6
0021-9193/05/$08.00+0     doi:10.1128/JB.187.6.2200-2202.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Gregory, S. T., Dahlberg, A. E. (2009). Genetic and structural analysis of base substitutions in the central pseudoknot of Thermus thermophilus 16S ribosomal RNA. RNA 15: 215-223 [Abstract] [Full Text]  
  • Felnagle, E. A., Rondon, M. R., Berti, A. D., Crosby, H. A., Thomas, M. G. (2007). Identification of the Biosynthetic Gene Cluster and an Additional Gene for Resistance to the Antituberculosis Drug Capreomycin. Appl. Environ. Microbiol. 73: 4162-4170 [Abstract] [Full Text]  
  • Gregory, S. T., Carr, J. F., Rodriguez-Correa, D., Dahlberg, A. E. (2005). Mutational Analysis of 16S and 23S rRNA Genes of Thermus thermophilus. J. Bacteriol. 187: 4804-4812 [Abstract] [Full Text]  


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