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Journal of Bacteriology, January 2006, p. 339-342, Vol. 188, No. 1
0021-9193/06/$08.00+0     doi:10.1128/JB.188.1.339-342.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Generation of DNA-Free Escherichia coli Cells by 2-Aminopurine Requires Mismatch Repair and Nonmethylated DNA

Ivan Matic,1* Damian Ekiert,2 Miroslav Radman,1 and Masamichi Kohiyama2

INSERM U571, Faculté de Médecine Necker-Université Paris V, 156 rue de Vaugirard, 75730 Paris Cedex 15, France,1 Institut Jacques Monod-CNRS, Universités Paris 6 & 7, 2 place Jussieu, 75251 Paris Cedex 05, France2

Received 20 July 2005/ Accepted 12 October 2005

Undirected mismatch repair initiated by the incorporation of the base analog 2-aminopurine kills DNA-methylation-deficient Escherichia coli dam cells by DNA double-strand breakage. Subsequently, the chromosomal DNA is totally degraded, resulting in DNA-free cells.

* Corresponding author. Mailing address: INSERM U571, Faculté de Médecine, Université Paris V, 156 rue Vaugirard, 75730 Paris Cedex 15, France. Phone: (33) 1 40 61 53 25. Fax: (33) 1 40 61 53 22. E-mail: matic{at}necker.fr.

Journal of Bacteriology, January 2006, p. 339-342, Vol. 188, No. 1
0021-9193/06/$08.00+0     doi:10.1128/JB.188.1.339-342.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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