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Journal of Bacteriology, July 2006, p. 4978-4982, Vol. 188, No. 13
0021-9193/06/$08.00+0     doi:10.1128/JB.00025-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

GlnR-Mediated Regulation of Nitrogen Metabolism in Lactococcus lactis

Rasmus Larsen ,{dagger},§ Tomas G. Kloosterman,{dagger} Jan Kok, and Oscar P. Kuipers*

Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands

Received 9 January 2006/ Accepted 4 April 2006

We show that the nitrogen regulatory protein GlnR of Lactococcus lactis represses transcription of the amtB-glnK, glnRA, and glnPQ operons. This likely occurs through a conserved DNA motif, 5'-TGTNA-7N-TNACAT-3', and takes place in response to extracellular glutamine and ammonium. GlnR-independent repression of amtB-glnK is mediated by the pleiotropic nitrogen regulator CodY.

* Corresponding author. Mailing address: Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands. Phone: 31-50-3632093. Fax: 31-50-3632348. E-mail: O.P.Kuipers{at}rug.nl.

{dagger} These authors contributed equally to this study.

§ Present address: Inflammation Group, Instituto Gulbenkian de Ciência, Apartado 14, 2781-901 Oeiras, Portugal.

Journal of Bacteriology, July 2006, p. 4978-4982, Vol. 188, No. 13
0021-9193/06/$08.00+0     doi:10.1128/JB.00025-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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