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Journal of Bacteriology, August 2006, p. 6034-6038, Vol. 188, No. 16
0021-9193/06/$08.00+0     doi:10.1128/JB.00340-06

The Mycobacterium-Specific Gene Rv2719c Is DNA Damage Inducible Independently of RecA{dagger}

Patricia C. Brooks, Lisa F. Dawson, Lucinda Rand,{ddagger} and Elaine O. Davis*

Division of Mycobacterial Research, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom

Received 9 March 2006/ Accepted 31 May 2006

The mycobacterium-specific gene Rv2719c was found to be expressed primarily from a promoter that was clearly DNA damage inducible independently of RecA. Upstream of the transcriptional start site for this promoter, sequence motifs resembling those observed previously at the RecA-independent, DNA damage-inducible recA promoter were identified, and the –10 motif was demonstrated by mutational analysis in transcriptional fusion constructs to be important for expression of Rv2719c.

* Corresponding author. Mailing address: Division of Mycobacterial Research, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom. Phone: 020 8959 3666. Fax: 020 8913 8528. E-mail: edavis{at}nimr.mrc.ac.uk.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

{ddagger} Present address: TB Unit, 10 Biopolis Road, #05-01 Chromos, Singapore 138670.

Journal of Bacteriology, August 2006, p. 6034-6038, Vol. 188, No. 16
0021-9193/06/$08.00+0     doi:10.1128/JB.00340-06




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