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Journal of Bacteriology, September 2006, p. 6425-6428, Vol. 188, No. 17
0021-9193/06/$08.00+0     doi:10.1128/JB.00427-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

ScoC and SinR Negatively Regulate epr by Corepression in Bacillus subtilis

Prashant Kodgire, Madhulika Dixit,{dagger} and K. Krishnamurthy Rao*

School of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India

Received 27 March 2006/ Accepted 16 June 2006

Negative regulation of epr in Bacillus subtilis 168 is mediated jointly by both ScoC and SinR, which bind to their respective target sites 62 bp apart. Increasing the distance between the two sites abolishes repression, indicating that the two proteins interact, thereby suggesting a mechanism of corepression.

* Corresponding author. Mailing address: Gene Regulation Lab, School of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India. Phone: (91) (22) 2576 7776. Fax: (91) (22) 2572 3480. E-mail: kkr{at}iitb.ac.in.

{dagger} Present address: Vascular Signalling Group, Institute of Cardiovascular Physiology, Johann Wolfgang Goethe University, 60590 Frankfurt am Main, Germany.

Journal of Bacteriology, September 2006, p. 6425-6428, Vol. 188, No. 17
0021-9193/06/$08.00+0     doi:10.1128/JB.00427-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Kodgire, P., Rao, K. K. (2009). hag expression in Bacillus subtilis is both negatively and positively regulated by ScoC. Microbiology 155: 142-149 [Abstract] [Full Text]  


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