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Journal of Bacteriology, January 2006, p. 789-793, Vol. 188, No. 2
0021-9193/06/$08.00+0     doi:10.1128/JB.188.2.789-793.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Autorepression of RctB, an Initiator of Vibrio cholerae Chromosome II Replication{dagger}

Elizabeth S. Egan, Stephane Duigou, and Matthew K. Waldor*

Genetics Program and Department of Molecular Microbiology, Tufts University School of Medicine and Howard Hughes Medical Institute, 136 Harrison Ave., Boston, Massachusetts 02111

Received 10 August 2005/ Accepted 17 October 2005

The RctB protein binds to the origin of replication of Vibrio cholerae chromosome II (chrII) and is required for oriCIIVc-based replication. Here, we found that RctB acts as an autorepressor, inhibiting rctB transcription. Integration host factor promotes rctB transcription, while Dam and DnaA, factors required for replication of both V. cholerae chromosomes, influence RctB autorepression. Thus, RctB appears to regulate chrII replication as both an initiator and a transcription repressor, and its synthesis is modulated by factors that govern replication of both chromosomes.

* Corresponding author. Mailing address: Genetics Program and Department of Molecular Microbiology, Tufts University School of Medicine and Howard Hughes Medical Institute, 136 Harrison Ave., Boston, MA 02111. Phone: (617) 636-2730. Fax: (617) 636-2723. E-mail: matthew.waldor{at}tufts.edu.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, January 2006, p. 789-793, Vol. 188, No. 2
0021-9193/06/$08.00+0     doi:10.1128/JB.188.2.789-793.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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  • Duigou, S., Knudsen, K. G., Skovgaard, O., Egan, E. S., Lobner-Olesen, A., Waldor, M. K. (2006). Independent Control of Replication Initiation of the Two Vibrio cholerae Chromosomes by DnaA and RctB.. J. Bacteriol. 188: 6419-6424 [Abstract] [Full Text]  
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