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Journal of Bacteriology, November 2006, p. 7963-7965, Vol. 188, No. 22
0021-9193/06/$08.00+0     doi:10.1128/JB.00995-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Bile-Induced Curing of the Virulence Plasmid in Salmonella enterica Serovar Typhimurium{triangledown}

Meritxell García-Quintanilla, Ana I. Prieto, Laurent Barnes, Francisco Ramos-Morales, and Josep Casadesús*

Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Apartado 1095, Seville 41080, Spain

Received 7 July 2006/ Accepted 28 August 2006

Exposure to bile induces curing of the virulence plasmid in Salmonella enterica serovar Typhimurium (pSLT). Disruption of the ccdB gene increases pSLT curing, both spontaneous and induced by bile, suggesting that the pSLT ccdAB genes may encode a homolog of the CcdAB addiction module previously described in the F sex factor. Unlike the F sex factor, synthesis of pSLT-encoded pili does not confer bile sensitivity. These observations may provide insights into the evolution of virulence plasmids in Salmonella subspecies I, as well as the causes of virulence plasmid loss in other Salmonella subspecies.

* Corresponding author. Mailing address: Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Apartado 1095, E-41080 Seville, Spain. Phone: 34 95 455 7105. Fax: 34 95 455 7104. E-mail: casadesus{at}us.es.

{triangledown} Published ahead of print on 8 September 2006.

Journal of Bacteriology, November 2006, p. 7963-7965, Vol. 188, No. 22
0021-9193/06/$08.00+0     doi:10.1128/JB.00995-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Garcia-Quintanilla, M., Ramos-Morales, F., Casadesus, J. (2008). Conjugal Transfer of the Salmonella enterica Virulence Plasmid in the Mouse Intestine. J. Bacteriol. 190: 1922-1927 [Abstract] [Full Text]  


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