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Journal of Bacteriology, February 2006, p. 1184-1187, Vol. 188, No. 3
0021-9193/06/$08.00+0     doi:10.1128/JB.188.3.1184-1187.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Comparative Genomic Analysis of 18 Pseudomonas aeruginosa Bacteriophages{dagger}

Tony Kwan,1 Jing Liu,1 Michael DuBow,2 Philippe Gros,3 and Jerry Pelletier3*

Targanta Therapeutics, Inc., 7170 Frederick Banting, 2nd Floor, Ville Saint Laurent, Quebec, Canada H4S 2A1;,1 Institut de Génétique et Microbiologie, Université Paris Sud, Bâtiment 409, 91405 Orsay, France,2 Department of Biochemistry and McGill Cancer Center, McIntyre Medical Sciences Building, McGill University, Montréal, Québec, Canada H3G 1Y63

Received 15 August 2005/ Accepted 6 November 2005

A genomic analysis of 18 P. aeruginosa phages, including nine newly sequenced DNA genomes, indicates a tremendous reservoir of proteome diversity, with 55% of open reading frames (ORFs) being novel. Comparative sequence analysis and ORF map organization revealed that most of the phages analyzed displayed little relationship to each other.

* Corresponding author. Mailing address: McIntyre Medical Sciences Building, Room 810, 3655 Promenade Sir William Osler, McGill University, Montreal, Quebec, Canada H3G 1Y6. Phone: (514) 398-2323. Fax: (514) 398-7384. E-mail: jerry.pelletier{at}mcgill.ca.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, February 2006, p. 1184-1187, Vol. 188, No. 3
0021-9193/06/$08.00+0     doi:10.1128/JB.188.3.1184-1187.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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