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Journal of Bacteriology, February 2006, p. 1497-1508, Vol. 188, No. 4
0021-9193/06/$08.00+0     doi:10.1128/JB.188.4.1497-1508.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

The Bifunctional FtsK Protein Mediates Chromosome Partitioning and Cell Division in Caulobacter

Sherry C. E. Wang, Lisandra West, and Lucy Shapiro*

Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94304-5329

Received 29 August 2005/ Accepted 30 November 2005

Bacterial chromosome partitioning and cell division are tightly connected cellular processes. We show here that the Caulobacter crescentus FtsK protein localizes to the division plane, where it mediates multiple functions involved in chromosome segregation and cytokinesis. The first 258 amino acids of the N terminus are necessary and sufficient for targeting the protein to the division plane. Furthermore, the FtsK N terminus is required to either assemble or maintain FtsZ rings at the division plane. The FtsK C terminus is essential in Caulobacter and is involved in maintaining accurate chromosome partitioning. In addition, the C-terminal region of FtsK is required for the localization of the topoisomerase IV ParC subunit to the replisome to facilitate chromosomal decatenation prior to cell division. These results suggest that the interdependence between chromosome partitioning and cell division in Caulobacter is mediated, in part, by the FtsK protein.

* Corresponding author. Mailing address: Department of Developmental Biology, Stanford University School of Medicine, Beckman Center, B300, 279 Campus Dr., Stanford, CA 94304-5329. Phone: (650) 725-7678. Fax: (650) 725-7739. E-mail: shapiro{at}cmgm.stanford.edu.

Journal of Bacteriology, February 2006, p. 1497-1508, Vol. 188, No. 4
0021-9193/06/$08.00+0     doi:10.1128/JB.188.4.1497-1508.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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