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Journal of Bacteriology, February 2006, p. 1648-1659, Vol. 188, No. 4
0021-9193/06/$08.00+0     doi:10.1128/JB.188.4.1648-1659.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Global Transcriptome Analysis of Staphylococcus aureus Response to Hydrogen Peroxide{dagger}

Wook Chang,1 David A. Small,1 Freshteh Toghrol,2* and William E. Bentley1

Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, Maryland 20742,1 Microarray Research Laboratory, Biological and Economic Analysis Division, Office of Pesticide Programs, U.S. Environmental Protection Agency, Fort Meade, Maryland 207552

Received 20 October 2005/ Accepted 29 November 2005

Staphylococcus aureus responds with protective strategies against phagocyte-derived reactive oxidants to infect humans. Herein, we report the transcriptome analysis of the cellular response of S. aureus to hydrogen peroxide-induced oxidative stress. The data indicate that the oxidative response includes the induction of genes involved in virulence, DNA repair, and notably, anaerobic metabolism.

* Corresponding author. Mailing address: Microarray Research Laboratory, Biological and Economic Analysis Division, Office of Pesticide Programs, U.S. Environmental Protection Agency, Fort Meade, MD 20755. Phone: (410) 305-2755. Fax: (410) 305-3091. E-mail: toghrol.freshteh{at}epa.gov.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, February 2006, p. 1648-1659, Vol. 188, No. 4
0021-9193/06/$08.00+0     doi:10.1128/JB.188.4.1648-1659.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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