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Journal of Bacteriology, March 2006, p. 2244-2253, Vol. 188, No. 6
0021-9193/06/$08.00+0     doi:10.1128/JB.188.6.2244-2253.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Coordination between Chromosome Replication, Segregation, and Cell Division in Caulobacter crescentus

Rasmus B. Jensen*

Department of Life Sciences and Chemistry, Roskilde University, Universitetsvej 1, DK-4000 Roskilde, Denmark

Received 3 October 2005/ Accepted 14 December 2005

Progression through the Caulobacter crescentus cell cycle is coupled to a cellular differentiation program. The swarmer cell is replicationally quiescent, and DNA replication initiates at the swarmer-to-stalked cell transition. There is a very short delay between initiation of DNA replication and movement of one of the newly replicated origins to the opposite pole of the cell, indicating the absence of cohesion between the newly replicated origin-proximal parts of the Caulobacter chromosome. The terminus region of the chromosome becomes located at the invaginating septum in predivisional cells, and the completely replicated terminus regions stay associated with each other after chromosome replication is completed, disassociating very late in the cell cycle shortly before the final cell division event. Invagination of the cytoplasmic membrane occurs earlier than separation of the replicated terminus regions and formation of separate nucleoids, which results in trapping of a chromosome on either side of the cell division septum, indicating that there is not a nucleoid exclusion phenotype.

* Mailing address: Department of Life Sciences and Chemistry, Roskilde University, Universitetsvej 1, DK-4000 Roskilde, Denmark. Phone: 45 46742471. Fax: 45 46743011. E-mail: rbjensen{at}ruc.dk.

Journal of Bacteriology, March 2006, p. 2244-2253, Vol. 188, No. 6
0021-9193/06/$08.00+0     doi:10.1128/JB.188.6.2244-2253.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Goley, E.D., Toro, E., McAdams, H.H., Shapiro, L. (2009). Dynamic Chromosome Organization and Protein Localization Coordinate the Regulatory Circuitry that Drives the Bacterial Cell Cycle. Cold Spring Harb Symp Quant Biol 0: sqb.2009.74.005v2-sqb.2009.74.005 [Abstract]  
  • Goley, E. D., Iniesta, A. A., Shapiro, L. (2007). Cell cycle regulation in Caulobacter: location, location, location. J. Cell Sci. 120: 3501-3507 [Abstract] [Full Text]  
  • Jensen, R. B. (2006). Analysis of the Terminus Region of the Caulobacter crescentus Chromosome and Identification of the dif Site.. J. Bacteriol. 188: 6016-6019 [Abstract] [Full Text]  


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