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Journal of Bacteriology, March 2006, p. 2290-2293, Vol. 188, No. 6
0021-9193/06/$08.00+0     doi:10.1128/JB.188.6.2290-2293.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Genomic Comparison of Mycobacterium avium subsp. paratuberculosis Sheep and Cattle Strains by Microarray Hybridization{dagger}

Ian B. Marsh,1* John P. Bannantine,2 Michael L. Paustian,2 Mark L. Tizard,3 Vivek Kapur,4 and Richard J. Whittington1

Faculty of Veterinary Science, University of Sydney, Camden, NSW, Australia,1 National Animal Disease Center, United States Department of Agriculture, Agricultural Research Service, Ames, Iowa,2 CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia,3 Biomedical Genomics Center and Department of Microbiology, University of Minnesota, St. Paul, Minnesota4

Received 9 November 2005/ Accepted 21 December 2005

Microarray-based comparisons of three Mycobacterium avium subsp. paratuberculosis isolates, including one sheep strain and two cattle strains, identified three large genomic deletions in the sheep strain, totaling 29,208 bp and involving 24 open reading frames. These deletions may help explain some of the differences in pathogenicity and host specificity observed between the cattle and sheep strains of Mycobacterium avium subsp. paratuberculosis.

* Corresponding author. Mailing address: Elizabeth Macarthur Agricultural Institute, New South Wales Department of Primary Industries, PMB 8 Camden, NSW 2570, Australia. Phone: 61-2-46-406-502. Fax: 61-2-46-406-384. E-mail: ian.marsh{at}agric.nsw.gov.au.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, March 2006, p. 2290-2293, Vol. 188, No. 6
0021-9193/06/$08.00+0     doi:10.1128/JB.188.6.2290-2293.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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