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Journal of Bacteriology, April 2006, p. 3121-3125, Vol. 188, No. 8
0021-9193/06/$08.00+0     doi:10.1128/JB.188.8.3121-3125.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Mechanism of hilA Repression by 1,2-Propanediol Consists of Two Distinct Pathways, One Dependent on and the Other Independent of Catabolic Production of Propionate, in Salmonella enterica Serovar Typhimurium

Shu-ichi Nakayama* and Haruo Watanabe

Department of Bacteriology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan

Received 25 September 2005/ Accepted 25 January 2006

A glycerol dehydrogenase gene was selected as a multicopy suppressor rescuing the reduced hilA expression in the Salmonella enterica serovar Typhimurium cpxA mutant. A substrate of the enzyme, 1,2-propanediol, repressed hilA expression. The 1,2-propanediol-mediated repression at 150 mM, but not that at 300 mM, was abrogated by blocking the catabolism producing propionate from 1,2-propanediol.

* Corresponding author. Mailing address: Department of Bacteriology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan. Phone: 81-3-5285-1111, ext. 2226. Fax: 81-3-5285-1163. E-mail: shuichin{at}nih.go.jp.

Journal of Bacteriology, April 2006, p. 3121-3125, Vol. 188, No. 8
0021-9193/06/$08.00+0     doi:10.1128/JB.188.8.3121-3125.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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