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Journal of Bacteriology, April 2006, p. 3143-3148, Vol. 188, No. 8
0021-9193/06/$08.00+0     doi:10.1128/JB.188.8.3143-3148.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

BacA-Mediated Bleomycin Sensitivity in Sinorhizobium meliloti Is Independent of the Unusual Lipid A Modification

Gail P. Ferguson,1* An Jansen,2 Victoria L. Marlow,1 and Graham C. Walker2*

Institute of Structural and Molecular Biology and Centre for Science at Extreme Conditions, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JR, United Kingdom,1 Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 021392

Received 25 October 2005/ Accepted 27 January 2006

Sinorhizobium meliloti bacA mutants are symbiotically defective, deoxycholate sensitive, and bleomycin resistant. We show that the bleomycin resistance phenotype is independent of the lipid A alteration and that the changes giving rise to both phenotypes are likely to be involved in the inability of bacA mutants to persist within their hosts.

* Corresponding author. Mailing address for Graham C. Walker: Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139. Phone: (617) 253-7066. Fax: (617) 253-2643. E-mail: gwalker{at}mit.edu. Mailing address for Gail P. Ferguson: Institute of Structural and Molecular Biology and Centre for Science at Extreme Conditions, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JR, United Kingdom. Phone: 44 131 650 7066. Fax: 44 131 6501 3331. E-mail: G.Ferguson{at}ed.ac.uk.

Journal of Bacteriology, April 2006, p. 3143-3148, Vol. 188, No. 8
0021-9193/06/$08.00+0     doi:10.1128/JB.188.8.3143-3148.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Haag, A. F., Wehmeier, S., Beck, S., Marlow, V. L., Fletcher, V., James, E. K., Ferguson, G. P. (2009). The Sinorhizobium meliloti LpxXL and AcpXL Proteins Play Important Roles in Bacteroid Development within Alfalfa. J. Bacteriol. 191: 4681-4686 [Abstract] [Full Text]  
  • Marlow, V. L., Haag, A. F., Kobayashi, H., Fletcher, V., Scocchi, M., Walker, G. C., Ferguson, G. P. (2009). Essential Role for the BacA Protein in the Uptake of a Truncated Eukaryotic Peptide in Sinorhizobium meliloti. J. Bacteriol. 191: 1519-1527 [Abstract] [Full Text]  
  • Domenech, P., Kobayashi, H., LeVier, K., Walker, G. C., Barry, C. E. III (2009). BacA, an ABC Transporter Involved in Maintenance of Chronic Murine Infections with Mycobacterium tuberculosis. J. Bacteriol. 191: 477-485 [Abstract] [Full Text]  


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