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Journal of Bacteriology, April 2006, p. 3149-3152, Vol. 188, No. 8
0021-9193/06/$08.00+0     doi:10.1128/JB.188.8.3149-3152.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Characterization of a Gene Encoding an Acetylase Required for Pyoverdine Synthesis in Pseudomonas aeruginosa

Iain L. Lamont,* Lois W. Martin, Talia Sims, Amy Scott,{dagger} and Mary Wallace

Department of Biochemistry, University of Otago, Dunedin, New Zealand

Received 16 December 2005/ Accepted 6 February 2006

Strains of Pseudomonas aeruginosa secrete one of three pyoverdine siderophores (types I to III). We have characterized a gene, pvdYII (for the pvdY gene present in type II P. aeruginosa strains), that is only present in strains that make type II pyoverdine. A mutation in pvdYII prevented pyoverdine synthesis. Bioinformatic, genetic, and biochemical approaches indicate that the PvdYII enzyme catalyzes acetylation of hydroxyornithine. Expression of pvdYII is repressed by the presence of iron and upregulated by the presence of type II pyoverdine. Characterization of pvdYII provides insights into the molecular basis for production of different pyoverdines by different strains of P. aeruginosa.

* Corresponding author. Mailing address: Department of Biochemistry, University of Otago, P.O. Box 56, Dunedin, New Zealand. Phone: 64-3-479-7869. Fax: 64-3-479-7866. E-mail: iain.lamont{at}stonebow.otago.ac.nz.

{dagger} Present address: Christchurch School of Medicine, University of Otago, Christchurch, New Zealand.

Journal of Bacteriology, April 2006, p. 3149-3152, Vol. 188, No. 8
0021-9193/06/$08.00+0     doi:10.1128/JB.188.8.3149-3152.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Ge, L., Seah, S. Y. K. (2006). Heterologous Expression, Purification, and Characterization of an L-Ornithine N5-Hydroxylase Involved in Pyoverdine Siderophore Biosynthesis in Pseudomonas aeruginosa.. J. Bacteriol. 188: 7205-7210 [Abstract] [Full Text]  


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