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Journal of Bacteriology, January 2007, p. 220-227, Vol. 189, No. 1
0021-9193/07/$08.00+0     doi:10.1128/JB.01149-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Response of Staphylococcus aureus to Salicylate Challenge{triangledown}

James T. Riordan,1,2 Arunachalam Muthaiyan,3 Wayne Van Voorhies,2 Christopher T. Price,4 James E. Graham,4 Brian J. Wilkinson,3 and John E. Gustafson1,2*

Microbiology Group, Department of Biology,1 Molecular Biology Program, New Mexico State University, Las Cruces, New Mexico 88003-8001,2 Department of Biological Sciences, Illinois State University, Normal, Illinois 61791-4120,3 Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, Kentucky 402924

Received 23 July 2006/ Accepted 10 October 2006

Growth of Staphylococcus aureus with the nonsteroidal anti-inflammatory salicylate reduces susceptibility of the organism to multiple antimicrobials. Transcriptome analysis revealed that growth of S. aureus with salicylate leads to the induction of genes involved with gluconate and formate metabolism and represses genes required for gluconeogenesis and glycolysis. In addition, salicylate induction upregulates two antibiotic target genes and downregulates a multidrug efflux pump gene repressor (mgrA) and sarR, which represses a gene (sarA) important for intrinsic antimicrobial resistance. We hypothesize that these salicylate-induced alterations jointly represent a unique mechanism that allows S. aureus to resist antimicrobial stress and toxicity.

* Corresponding author. Mailing address: Department of Biology, New Mexico State University, P.O. Box 30001 Dept. 3AF, Las Cruces, NM 88003-8001. Phone: (505) 646-5660. Fax: (505) 646-5665. E-mail: jgustafs{at}nmsu.edu.

{triangledown} Published ahead of print on 20 October 2006.

Journal of Bacteriology, January 2007, p. 220-227, Vol. 189, No. 1
0021-9193/07/$08.00+0     doi:10.1128/JB.01149-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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