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Journal of Bacteriology, June 2007, p. 4310-4314, Vol. 189, No. 11
0021-9193/07/$08.00+0     doi:10.1128/JB.00240-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

The Anaerobic Regulatory Network Required for Pseudomonas aeruginosa Nitrate Respiration{triangledown}

Kerstin Schreiber,1 Robert Krieger,1,{dagger} Beatrice Benkert,1 Martin Eschbach,1,{ddagger} Hiroyuki Arai,2 Max Schobert,1 and Dieter Jahn1*

Institute of Microbiology, Technical University of Braunschweig, Spielmannstr. 7, D-38106 Braunschweig, Germany,1 Department of Biotechnology, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657, Japan2

Received 13 February 2007/ Accepted 16 March 2007

In Pseudomonas aeruginosa, the narK1K2GHJI operon encodes two nitrate/nitrite transporters and the dissimilatory nitrate reductase. The narK1 promoter is anaerobically induced in the presence of nitrate by the dual activity of the oxygen regulator Anr and the N-oxide regulator Dnr in cooperation with the nitrate-responsive two-component regulatory system NarXL. The DNA bending protein IHF is essential for this process. Similarly, narXL gene transcription is enhanced under anaerobic conditions by Anr and Dnr. Furthermore, Anr and NarXL induce expression of the N-oxide regulator gene dnr. Finally, NarXL in cooperation with Dnr is required for anaerobic nitrite reductase regulatory gene nirQ transcription. A cascade regulatory model for the fine-tuned genetic response of P. aeruginosa to anaerobic growth conditions in the presence of nitrate was deduced.

* Corresponding author. Mailing address: Institute of Microbiology, Technical University Braunschweig, Spielmannstr. 7, D-38106 Braunschweig, Germany. Phone: 49 531 391 5801. Fax: 49 531 5854. E-mail: d.jahn{at}tu-bs.de

{triangledown} Published ahead of print on 30 March 2007.

{dagger} Present address: Macherey-Nagel GmbH & Co. KG, Neumann-Neander-Str. 6-8, 52355 Dueren, Germany.

{ddagger} Present address: Institute of Experimental and Clinical Pharmacology and Toxicology, Albert-Ludwigs University Freiburg, Albertstr. 25, 79104 Freiburg, Germany.

Journal of Bacteriology, June 2007, p. 4310-4314, Vol. 189, No. 11
0021-9193/07/$08.00+0     doi:10.1128/JB.00240-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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