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Journal of Bacteriology, June 2007, p. 4320-4324, Vol. 189, No. 11
0021-9193/07/$08.00+0     doi:10.1128/JB.00003-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Control of Quorum Sensing by a Burkholderia pseudomallei Multidrug Efflux Pump{triangledown}

Ying Ying Chan,1 Hao Sheng Bian,1 Theresa May Chin Tan,1 Margrith E. Mattmann,2 Grant D. Geske,2 Jun Igarashi,3 Tomomi Hatano,3 Hiroaki Suga,3 Helen E. Blackwell,2 and Kim Lee Chua1*

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore,1 Department of Chemistry, University of Wisconsin—Madison, 1101 University Ave., Madison, Wisconsin 53706-1322,2 Chemical Biology and Biotechnology Lab, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan3

Received 2 January 2007/ Accepted 13 March 2007

The Burkholderia pseudomallei KHW quorum-sensing systems produced N-octanoyl-homoserine lactone, N-decanoyl-homoserine lactone, N-(3-hydroxy)-octanoyl-homoserine lactone, N-(3-hydroxy)-decanoyl-homoserine lactone, N-(3-oxo)-decanoyl-homoserine lactone, and N-(3-oxo)-tetradecanoyl-homoserine lactone. The extracellular secretion of these acyl-homoserine lactones is dependent absolutely on the function of the B. pseudomallei BpeAB-OprB efflux pump.

* Corresponding author. Mailing address: Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore. Phone: (65) 65163684. Fax: (65) 67791453. E-mail: bchckl{at}nus.edu.sg

{triangledown} Published ahead of print on 23 March 2007.

Journal of Bacteriology, June 2007, p. 4320-4324, Vol. 189, No. 11
0021-9193/07/$08.00+0     doi:10.1128/JB.00003-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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