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Journal of Bacteriology, July 2007, p. 5399-5402, Vol. 189, No. 14
0021-9193/07/$08.00+0     doi:10.1128/JB.00300-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Two ABC Transporter Operons and the Antimicrobial Resistance Gene mtrF Are pilT Responsive in Neisseria gonorrhoeae{triangledown}

Alexandra Friedrich,1* Cindy G. Arvidson,2 William M. Shafer,3,4 Eun-Hee Lee,3 and Magdalene So1,{dagger}

Department of Molecular Microbiology and Immunology, L220, Oregon Health Sciences University, Portland, Oregon 97201-3098,1 Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 48824,2 Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322,3 Laboratories of Bacterial Pathogenesis, VA Medical Center, Decatur, Georgia 300334

Received 28 February 2007/ Accepted 7 May 2007

Retraction of type IV pili is mediated by PilT. We show that loss of pilT function leads to upregulation of mtrF (multiple transferable resistance) and two operons encoding putative ABC transporters in Neisseria gonorrhoeae MS11. This effect occurs indirectly through the transcriptional regulator FarR, which until now has been shown to regulate only farAB. L-Glutamine can reverse pilT downregulation of the ABC transporter operons and mtrF.

* Corresponding author. Present address: Max Planck Institute for Infection Biology, Charitéplatz 1, D-10117 Berlin, Germany. Phone: 49 3028460455. Fax: 49 3028460401. E-mail: friedrich{at}mpiib-berlin.mpg.de

{triangledown} Published ahead of print on 11 May 2007.

{dagger} Present address: University of Arizona, Tucson, AZ 85719.

Journal of Bacteriology, July 2007, p. 5399-5402, Vol. 189, No. 14
0021-9193/07/$08.00+0     doi:10.1128/JB.00300-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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