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Journal of Bacteriology, September 2007, p. 6276-6283, Vol. 189, No. 17
0021-9193/07/$08.00+0     doi:10.1128/JB.00348-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Molecular Characterization of Class 3 Integrons from Delftia spp.{triangledown}

Hai Xu, Julian Davies, and Vivian Miao*

Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada

Received 8 March 2007/ Accepted 5 June 2007

Two environmental strains, Delftia acidovorans C17 and Delftia tsuruhatensis A90, were found to carry class 3 integrons, which have seldom been reported and then only from pathogens in which they are associated with antibiotic resistance genes. The Delftia integrons comprised a highly conserved class 3 integrase gene, upstream and oppositely oriented from a set of three or four gene cassettes that encoded unidentified functions. The A90 integron had one more gene cassette than the C17 integron, but the two were otherwise the same; furthermore, they were located within regions of sequence identity in both strains and linked to chromosomal genes. A screen of other Delftia and related strains did not reveal the presence of additional class 3 integrons. The observations suggest that these integrons were horizontally transferred to Delftia as part of a larger region and reside as chromosomal elements that probably predate transposon dissemination, as has been proposed for certain class 1 integrons.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Life Science Centre, University of British Columbia, 2350 Life Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada. Phone: (604) 822-9308. Fax: (604) 822-6041. E-mail: vmiao{at}telus.net

{triangledown} Published ahead of print on 15 June 2007.

Journal of Bacteriology, September 2007, p. 6276-6283, Vol. 189, No. 17
0021-9193/07/$08.00+0     doi:10.1128/JB.00348-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Larouche, A., Roy, P. H. (2009). Analysis by Mutagenesis of a Chromosomal Integron Integrase from Shewanella amazonensis SB2BT. J. Bacteriol. 191: 1933-1940 [Abstract] [Full Text]  
  • Gillings, M., Boucher, Y., Labbate, M., Holmes, A., Krishnan, S., Holley, M., Stokes, H. W. (2008). The Evolution of Class 1 Integrons and the Rise of Antibiotic Resistance. J. Bacteriol. 190: 5095-5100 [Abstract] [Full Text]  


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