This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Prunier, A.-L.
Right arrow Articles by Maurelli, A. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Prunier, A.-L.
Right arrow Articles by Maurelli, A. T.

 Previous Article  |  Next Article 

Journal of Bacteriology, September 2007, p. 6482-6486, Vol. 189, No. 17
0021-9193/07/$08.00+0     doi:10.1128/JB.00525-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Genetic Structure of the nadA and nadB Antivirulence Loci in Shigella spp.{triangledown}

Anne-Laure Prunier, Raymond Schuch,{dagger} Reinaldo E. Fernández, and Anthony T. Maurelli*

Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, F. Edward Hébert School of Medicine, Bethesda, Maryland 20814-4799

Received 5 April 2007/ Accepted 18 June 2007

Comparison of nadA and nadB in 14 Shigella strains and enteroinvasive Escherichia coli versus E. coli showed that at least one locus is altered in all strains. These observations explain the characteristic nicotinic acid auxotrophy of Shigella organisms and are consistent with the previously identified antivirulence nature of these genes for these pathogens.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, F. Edward Hébert School of Medicine, 4301 Jones Bridge Road, Bethesda, MD 20814-4799. Phone: (301) 295-3415. Fax: (301) 295-1545. E-mail: amaurelli{at}usuhs.mil

{triangledown} Published ahead of print on 22 June 2007.

{dagger} Present address: Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10021.

Journal of Bacteriology, September 2007, p. 6482-6486, Vol. 189, No. 17
0021-9193/07/$08.00+0     doi:10.1128/JB.00525-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Sun, Y.-C., Hinnebusch, B. J., Darby, C. (2008). From the Cover: Experimental evidence for negative selection in the evolution of a Yersinia pestis pseudogene. Proc. Natl. Acad. Sci. USA 105: 8097-8101 [Abstract] [Full Text]  
  • Schroeder, G. N., Hilbi, H. (2008). Molecular Pathogenesis of Shigella spp.: Controlling Host Cell Signaling, Invasion, and Death by Type III Secretion. Clin. Microbiol. Rev. 21: 134-156 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»