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Journal of Bacteriology, September 2007, p. 6635-6644, Vol. 189, No. 18
0021-9193/07/$08.00+0     doi:10.1128/JB.00640-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Rcs and PhoPQ Regulatory Overlap in the Control of Salmonella enterica Virulence{triangledown}

Clara B. García-Calderón, Josep Casadesús, and Francisco Ramos-Morales*

Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Apartado 1095, 41080 Sevilla, Spain

Received 24 April 2007/ Accepted 28 June 2007

Genetic screens based on the use of MudJ-generated lac fusions permitted the identification of novel genes regulated by the Rcs signal transduction system in Salmonella enterica serovar Typhimurium. Besides genes that are also found in the Escherichia coli genome, our screens identified Salmonella-specific genes regulated by RcsB, including bapA, siiE, srfA, and srfB. Here we show that the srfABC operon is negatively regulated by RcsB and by PhoP. In vivo studies using mutants with constitutive activation of the Rcs and/or PhoPQ system suggested that there is an overlap between these regulatory systems in the control of Salmonella virulence.

* Corresponding author. Mailing address: Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Avda Reina Mercedes, 6, 41012 Sevilla, Spain. Phone: 34 95 455 7107. Fax: 34 95 455 7104. E-mail: framos{at}us.es

{triangledown} Published ahead of print on 6 July 2007.

Journal of Bacteriology, September 2007, p. 6635-6644, Vol. 189, No. 18
0021-9193/07/$08.00+0     doi:10.1128/JB.00640-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Garcia-Calderon, C. B., Casadesus, J., Ramos-Morales, F. (2009). Regulation of igaA and the Rcs System by the MviA Response Regulator in Salmonella enterica. J. Bacteriol. 191: 2743-2752 [Abstract] [Full Text]  
  • Mariscotti, J. F., Garcia-del Portillo, F. (2009). Genome Expression Analyses Revealing the Modulation of the Salmonella Rcs Regulon by the Attenuator IgaA. J. Bacteriol. 191: 1855-1867 [Abstract] [Full Text]  
  • Wang, Q., Zhao, Y., McClelland, M., Harshey, R. M. (2007). The RcsCDB Signaling System and Swarming Motility in Salmonella enterica Serovar Typhimurium: Dual Regulation of Flagellar and SPI-2 Virulence Genes. J. Bacteriol. 189: 8447-8457 [Abstract] [Full Text]  


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