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Journal of Bacteriology, September 2007, p. 6686-6694, Vol. 189, No. 18
0021-9193/07/$08.00+0     doi:10.1128/JB.00489-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

SbcCD Regulation and Localization in Escherichia coli{triangledown}

Elise Darmon, Manuel A. Lopez-Vernaza, Anne C. Helness, Amanda Borking, Emily Wilson, Zubin Thacker, Laura Wardrope, and David R. F. Leach*

Institute of Cell Biology, University of Edinburgh, Kings Buildings, Edinburgh EH9 3JR, United Kingdom

Received 30 March 2007/ Accepted 10 July 2007

The SbcCD complex and its homologues play important roles in DNA repair and in the maintenance of genome stability. In Escherichia coli, the in vitro functions of SbcCD have been well characterized, but its exact cellular role remains elusive. This work investigates the regulation of the sbcDC operon and the cellular localization of the SbcC and SbcD proteins. Transcription of the sbcDC operon is shown to be dependent on starvation and RpoS protein. Overexpressed SbcC protein forms foci that colocalize with the replication factory, while overexpressed SbcD protein is distributed through the cytoplasm.

* Corresponding author. Mailing address: Institute of Cell and Molecular Biology, University of Edinburgh, Kings Buildings, Edinburgh EH9 3JR, United Kingdom. Phone: 44 131 650 53 73. Fax: 44 131 650 86 50. E-mail: d.leach{at}ed.ac.uk

{triangledown} Published ahead of print on 20 July 2007.

Journal of Bacteriology, September 2007, p. 6686-6694, Vol. 189, No. 18
0021-9193/07/$08.00+0     doi:10.1128/JB.00489-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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