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Journal of Bacteriology, January 2007, p. 650-655, Vol. 189, No. 2
0021-9193/07/$08.00+0     doi:10.1128/JB.01437-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Contribution of Invariant Residues to the Function of Rgg Family Transcription Regulators{triangledown} ,{ddagger}

Jennifer A. Loughman{dagger} and Michael G. Caparon*

Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri 63110

Received 11 September 2006/ Accepted 30 October 2006

The Rgg family of transcription regulators is widely distributed among gram-positive bacteria, yet how these proteins control transcription is poorly understood. Using Streptococcus pyogenes RopB as a model, we demonstrated that residues invariant among Rgg-like regulators are critical for function and obtained evidence for a mechanism involving protein complex formation.

* Corresponding author. Mailing address: Department of Molecular Microbiology, Washington University School of Medicine, 660 S. Euclid Ave., Box 8230, Saint Louis, MO 63110-1093. Phone: (314) 362-1485. Fax: (314) 362-3203. E-mail: caparon{at}borcim.wustl.edu.

{triangledown} Published ahead of print on 10 November 2006.

{ddagger} Supplemental material for this article may be found at http://jb.asm.org/.

{dagger} Present address: Department of Pediatrics, Washington University School of Medicine, 660 S. Euclid Ave., Box 8208, Saint Louis, MO 63110-1093.

Journal of Bacteriology, January 2007, p. 650-655, Vol. 189, No. 2
0021-9193/07/$08.00+0     doi:10.1128/JB.01437-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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