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Journal of Bacteriology, November 2007, p. 8366-8370, Vol. 189, No. 22
0021-9193/07/$08.00+0     doi:10.1128/JB.01066-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Interplay between the Temperate Phages PY54 and N15, Linear Plasmid Prophages with Covalently Closed Ends{triangledown}

Jens A. Hammerl,1,3 Iris Klein,2 Bernd Appel,1 and Stefan Hertwig1*

Bundesinstitut für Risikobewertung, D-12277 Berlin, Germany,1 Robert Koch-Institut, D-13353 Berlin, Germany,2 Max-Planck-Institut für Molekulare Genetik, D-14195 Berlin, Germany3

Received 6 July 2007/ Accepted 28 August 2007

The objective of this study was to determine whether the temperate Yersinia enterocolitica phage PY54 may interact with the related Escherichia coli phage N15 during both the lysogenic and the lytic cycle in the same cell. The PY54 and N15 prophages are linear plasmids which have been shown to be compatible and stably replicating in E. coli and Yersinia. In E. coli, the PY54 prophage does not restrict N15 propagation. In contrast, N15 reduces by use of its cor gene the susceptibility of Yersinia strains to PY54. Doubly lysogenic E. coli strains release PY54 virions, some of which apparently contain the N15 genome. Further experiments with replicative miniplasmid derivatives of PY54, N15, and the related Klebsiella oxytoca phage {phi}KO2 demonstrated that the {phi}KO2 and N15 plasmid prophages belong to the same incompatibility group.

* Corresponding author. Mailing address: Bundesinstitut für Risikobewertung, Molekulare Diagnostik und Genetik, Diedersdorfer Weg 1, D-12277 Berlin, Germany. Phone: 49-30-8412-2019. Fax: 49-30-8412-2000. E-mail: stefan.hertwig{at}bfr.bund.de

{triangledown} Published ahead of print on 7 September 2007.

Journal of Bacteriology, November 2007, p. 8366-8370, Vol. 189, No. 22
0021-9193/07/$08.00+0     doi:10.1128/JB.01066-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Zabala, B., Hammerl, J. A., Espejo, R. T., Hertwig, S. (2009). The Linear Plasmid Prophage Vp58.5 of Vibrio parahaemolyticus Is Closely Related to the Integrating Phage VHML and Constitutes a New Incompatibility Group of Telomere Phages. J. Virol. 83: 9313-9320 [Abstract] [Full Text]  


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