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Journal of Bacteriology, February 2007, p. 1464-1467, Vol. 189, No. 4
0021-9193/07/$08.00+0     doi:10.1128/JB.01153-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Group B Streptococcal Pilus Proteins Contribute to Adherence to and Invasion of Brain Microvascular Endothelial Cells{triangledown}

Heather C. Maisey, Mary Hensler, Victor Nizet, and Kelly S. Doran*

Department of Pediatrics, Division of Pharmacology & Drug Discovery, University of California, San Diego School of Medicine, La Jolla, California 92093

Received 28 July 2006/ Accepted 4 October 2006

Surface filamentous structures known as pili have been discovered recently in the gram-positive streptococcal pathogens that cause invasive disease in humans, including group B Streptococcus (GBS). We show that two GBS proteins involved in pilus formation, encoded by pilA and pilB, also facilitate the interaction of this important agent of central nervous system infection with endothelial cells of the human blood-brain barrier.

* Corresponding author. Mailing address: Department of Pediatrics, Division of Pharmacology & Drug Discovery, University of California, San Diego School of Medicine, La Jolla, CA 92093. Phone: (858) 822-4260. Fax: (858) 534-5611. E-mail: kdoran{at}ucsd.edu.

{triangledown} Published ahead of print on 13 October 2006.

Journal of Bacteriology, February 2007, p. 1464-1467, Vol. 189, No. 4
0021-9193/07/$08.00+0     doi:10.1128/JB.01153-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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