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Journal of Bacteriology, March 2007, p. 2139-2144, Vol. 189, No. 5
0021-9193/07/$08.00+0     doi:10.1128/JB.01653-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Evidence that RpoS ({sigma}S) in Borrelia burgdorferi Is Controlled Directly by RpoN ({sigma}54/{sigma}N){triangledown}

Alexandra H. Smith,1 Jon S. Blevins,1 Gulnaz N. Bachlani,1 Xiaofeng F. Yang,2 and Michael V. Norgard1*

Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390,1 Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 462022

Received 25 October 2006/ Accepted 28 November 2006

The alternative sigma factor (RpoN-RpoS) pathway controls the expression of key virulence factors in Borrelia burgdorferi. However, evidence to support whether RpoN controls rpoS directly or, perhaps, indirectly via a transactivator has been lacking. Herein we provide biochemical and genetic evidence that RpoN directly controls rpoS in B. burgdorferi.

* Corresponding author. Mailing address: Department of Microbiology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd., Dallas, TX 75390-9048. Phone: (214) 648-5900. Fax: (214) 648-5905. E-mail: michael.norgard{at}utsouthwestern.edu.

{triangledown} Published ahead of print on 8 December 2006.

Journal of Bacteriology, March 2007, p. 2139-2144, Vol. 189, No. 5
0021-9193/07/$08.00+0     doi:10.1128/JB.01653-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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