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Journal of Bacteriology, May 2008, p. 3768-3773, Vol. 190, No. 10
0021-9193/08/$08.00+0     doi:10.1128/JB.00058-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Evidence that AphB, Essential for the Virulence of Vibrio vulnificus, Is a Global Regulator {triangledown} ,{dagger}

Hee Gon Jeong and Sang Ho Choi*

National Research Laboratory of Molecular Microbiology and Toxicology, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, South Korea

Received 12 January 2008/ Accepted 4 March 2008

The Vibrio vulnificus aphB mutant was significantly less virulent than the wild type and was impaired in motility and adherence to host cells. Microarray analysis revealed that AphB of V. vulnificus (AphBVv) influences the expression of over 10% of the V. vulnificus genome. The combined results indicated that AphBVv is a global regulator contributing to the pathogenesis of V. vulnificus.

* Corresponding author. Mailing address: Department of Agricultural Biotechnology, Seoul National University, Seoul 151-742, South Korea. Phone: 82-2-880-4857. Fax: 82-2-873-5095. E-mail: choish{at}snu.ac.kr

{triangledown} Published ahead of print on 14 March 2008.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, May 2008, p. 3768-3773, Vol. 190, No. 10
0021-9193/08/$08.00+0     doi:10.1128/JB.00058-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Jones, M. K., Oliver, J. D. (2009). Vibrio vulnificus: Disease and Pathogenesis. Infect. Immun. 77: 1723-1733 [Full Text]  
  • Oh, M. H., Lee, S. M., Lee, D. H., Choi, S. H. (2009). Regulation of the Vibrio vulnificus hupA Gene by Temperature Alteration and Cyclic AMP Receptor Protein and Evaluation of Its Role in Virulence. Infect. Immun. 77: 1208-1215 [Abstract] [Full Text]  
  • Lee, D. H., Jeong, H. S., Jeong, H. G., Kim, K. M., Kim, H., Choi, S. H. (2008). A Consensus Sequence for Binding of SmcR, a Vibrio vulnificus LuxR Homologue, and Genome-wide Identification of the SmcR Regulon. J. Biol. Chem. 283: 23610-23618 [Abstract] [Full Text]  


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