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Journal of Bacteriology, May 2008, p. 3786-3790, Vol. 190, No. 10
0021-9193/08/$08.00+0     doi:10.1128/JB.01994-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

The GTPase CpgA Is Implicated in the Deposition of the Peptidoglycan Sacculus in Bacillus subtilis{triangledown}

Cédric Absalon,1,{dagger} Kassem Hamze,1 Didier Blanot,2 Claude Frehel,3 Rut Carballido-Lopez,4 Barry I. Holland,1 Jean van Heijenoort,2 and Simone J. Séror1*

Université Paris-Sud 11, Institut de Génétique et Microbiologie, CNRS UMR 8621, Bâtiment 409, 91405 Orsay Cedex, France,1 Université Paris-Sud 11, Institut de Biochimie et Biophysique Moléculaire et Cellulaire, CNRS UMR 8619, Bâtiment 430, 91405 Orsay Cedex, France,2 Institut National de la Santé et de la Recherche Médicale, U-570, CHU Necker, Enfants Malades, 156 Rue de Vaugirard, 75730 Paris Cedex 15, France,3 Institut National de la Recherche Agronomique, UR 895, Génétique Microbienne, Dynamique du Génome-Génomique, Domaine de Vilvert, 78352 Jouy-en-Josas Cedex, France4

Received 21 December 2007/ Accepted 4 March 2008

Depletion of the Bacillus subtilis GTPase CpgA produces abnormal cell shapes, nonuniform deposition of cell wall, and five- to sixfold accumulation of peptidoglycan precursors. Nevertheless, the inherent structure of the cell wall appeared mostly unchanged. The results are consistent with CpgA being involved in coordinating normal peptidoglycan deposition.

* Corresponding author. Mailing address: Université Paris-Sud 11, Institut de Génétique et Microbiologie, CNRS UMR 8621, Bâtiment 409, 91405 Orsay Cedex, France. Phone: 33 1 69 15 57 14. Fax: 33 1 69 15 78 08. E-mail: simone.seror{at}igmors.u-psud.fr

{triangledown} Published ahead of print on 14 March 2008.

{dagger} Present address: Division of Infectious Disease, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115.

Journal of Bacteriology, May 2008, p. 3786-3790, Vol. 190, No. 10
0021-9193/08/$08.00+0     doi:10.1128/JB.01994-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Absalon, C., Obuchowski, M., Madec, E., Delattre, D., Holland, I. B., Seror, S. J. (2009). CpgA, EF-Tu and the stressosome protein YezB are substrates of the Ser/Thr kinase/phosphatase couple, PrkC/PrpC, in Bacillus subtilis. Microbiology 155: 932-943 [Abstract] [Full Text]  


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