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Journal of Bacteriology, June 2008, p. 4079-4083, Vol. 190, No. 11
0021-9193/08/$08.00+0     doi:10.1128/JB.01889-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

The Gene Encoding RNase III in Streptomyces coelicolor Is Transcribed during Exponential Phase and Is Required for Antibiotic Production and for Proper Sporulation{triangledown}

Jason K. Sello* and Mark J. Buttner

Department of Molecular Microbiology, John Innes Centre, Norwich Research Park, Colney, NR4 7UH Norwich, United Kingdom

Received 3 December 2007/ Accepted 10 March 2008

Phenotypic analysis of a constructed RNase III null mutant of Streptomyces coelicolor revealed that RNase III is required for both antibiotic production and proper formation of sporulation septa. Transcriptional analysis of the gene encoding RNase III indicated that it is transcribed exclusively during exponential phase as part of a tricistronic message.

* Corresponding author. Present address: Department of Chemistry, Brown University, 324 Brook Street, Providence, RI 02912. Phone: (401) 863-1194. Fax: (401) 863-9046. E-mail: jason_sello{at}brown.edu

{triangledown} Published ahead of print on 21 March 2008.

Journal of Bacteriology, June 2008, p. 4079-4083, Vol. 190, No. 11
0021-9193/08/$08.00+0     doi:10.1128/JB.01889-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Gravenbeek, M. L., Jones, G. H. (2008). The endonuclease activity of RNase III is required for the regulation of antibiotic production by Streptomyces coelicolor. Microbiology 154: 3547-3555 [Abstract] [Full Text]  
  • Xu, W., Huang, J., Cohen, S. N. (2008). Autoregulation of AbsB (RNase III) Expression in Streptomyces coelicolor by Endoribonucleolytic Cleavage of absB Operon Transcripts. J. Bacteriol. 190: 5526-5530 [Abstract] [Full Text]  


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