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Journal of Bacteriology, June 2008, p. 4091-4094, Vol. 190, No. 11
0021-9193/08/$08.00+0     doi:10.1128/JB.00233-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

The Methanothermobacter thermautotrophicus Cdc6-2 Protein, the Putative Helicase Loader, Dissociates the Minichromosome Maintenance Helicase{triangledown}

Jae-Ho Shin,1,{dagger} Gun Young Heo,2,{dagger} and Zvi Kelman2*

School of Applied Biosciences, Kyungpook National University, Daegu 702-701, Republic of Korea,1 University of Maryland Biotechnology Institute, Center for Advanced Research in Biotechnology, 9600 Gudelsky Drive, Rockville, Maryland 208502

Received 15 February 2008/ Accepted 24 March 2008

The Cdc6-1 and -2 proteins from the archaeon Methanothermobacter thermautotrophicus were previously shown to bind the minichromosome maintenance (MCM) helicase. It is shown here that Cdc6-2 protein dissociates the MCM complex. This observation supports the hypothesis that the Cdc6-2 protein functions as a helicase loader.

* Corresponding author. Mailing address: University of Maryland Biotechnology Institute, Center for Advanced Research in Biotechnology, 9600 Gudelsky Drive, Rockville, MD 20850. Phone: (240) 314-6294. Fax: (240) 314-6255. E-mail: kelman{at}umbi.umd.edu

{triangledown} Published ahead of print on 4 April 2008.

{dagger} These authors contributed equally to the study.

Journal of Bacteriology, June 2008, p. 4091-4094, Vol. 190, No. 11
0021-9193/08/$08.00+0     doi:10.1128/JB.00233-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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