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Journal of Bacteriology, July 2008, p. 4754-4758, Vol. 190, No. 13
0021-9193/08/$08.00+0     doi:10.1128/JB.00131-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Spontaneous Amplification of the Actinorhodin Gene Cluster in Streptomyces coelicolor Involving Native Insertion Sequence IS466{triangledown}

E. M. Widenbrant,1* Hsiu-Hui Tsai,2 Carton W. Chen,2 and C. M. Kao1

Department of Chemical Engineering, Stanford University, Stanford, California 94305,1 Institute of Genetics, National Yang-Ming University, Shih-Pai, Taipei 112, Taiwan2

Received 24 January 2008/ Accepted 15 April 2008

We observed a spontaneous amplification of the Streptomyces coelicolor chromosome, including genes encoding biosynthetic enzymes of the antibiotic actinorhodin. A new junction of two tandem segments has, inserted within it, a third copy of a transposable element existing in two places elsewhere in the chromosome, suggesting its involvement in the amplification mechanism.

* Corresponding author. Mailing address: Department of Chemical Engineering, Stanford University, Stanford, CA 94305. Phone: (650) 723-4906. Fax: (650) 723-9780. E-mail: ewidenbrant{at}stanfordalumni.org

{triangledown} Published ahead of print on 25 April 2008.

Journal of Bacteriology, July 2008, p. 4754-4758, Vol. 190, No. 13
0021-9193/08/$08.00+0     doi:10.1128/JB.00131-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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