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Journal of Bacteriology, August 2008, p. 5522-5525, Vol. 190, No. 15
0021-9193/08/$08.00+0     doi:10.1128/JB.00312-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Virulence Gene Expression Is Independent of ResDE-Regulated Respiration Control in Bacillus anthracis{triangledown} ,{dagger}

Adam C. Wilson, James A. Hoch, and Marta Perego*

Division of Cellular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037

Received 29 February 2008/ Accepted 25 May 2008

The ResDE two-component system regulates the synthesis of several components of the aerobic and anaerobic respiratory pathways in bacilli. The ResD response regulator transcription factor has been implicated in the regulation of virulence factors in a number of gram-positive species, including Bacillus anthracis. The precise deletions of resD and resE in B. anthracis that retained the classical respiratory phenotypes did not affect the expression of the gene for the protective antigen of the anthrax toxin, pagA, or that of the toxin regulator, atxA. The results indicate that the loss of ResDE-controlled respiratory capacity does not affect the synthesis of anthrax toxin.

* Corresponding authors: Division of Cellular Biology, Mail Code MEM-116, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037. Phone: (858) 784-7912. Fax: (858) 784-7966. E-mail: mperego{at}scripps.edu

{triangledown} Published ahead of print on 6 June 2008.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, August 2008, p. 5522-5525, Vol. 190, No. 15
0021-9193/08/$08.00+0     doi:10.1128/JB.00312-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Esbelin, J., Armengaud, J., Zigha, A., Duport, C. (2009). ResDE-Dependent Regulation of Enterotoxin Gene Expression in Bacillus cereus: Evidence for Multiple Modes of Binding for ResD and Interaction with Fnr. J. Bacteriol. 191: 4419-4426 [Abstract] [Full Text]  
  • Somerville, G. A., Proctor, R. A. (2009). At the Crossroads of Bacterial Metabolism and Virulence Factor Synthesis in Staphylococci. Microbiol. Mol. Biol. Rev. 73: 233-248 [Abstract] [Full Text]  


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