This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Paige, C.
Right arrow Articles by Claiborne, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Paige, C.
Right arrow Articles by Claiborne, A.

 Previous Article  |  Next Article 

Journal of Bacteriology, September 2008, p. 6271-6275, Vol. 190, No. 18
0021-9193/08/$08.00+0     doi:10.1128/JB.00860-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

The Type III Pantothenate Kinase Encoded by coaX Is Essential for Growth of Bacillus anthracis{triangledown}

Carleitta Paige,1 Sean D. Reid,2 Philip C. Hanna,3 and Al Claiborne1*

Center for Structural Biology,1 Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157,2 Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 481093

Received 24 June 2008/ Accepted 3 July 2008

In Bacillus anthracis, the novel type III pantothenate kinase (PanKBa; encoded by coaX) catalyzes the first committed step in coenzyme A biosynthesis. We have demonstrated by analyzing the growth characteristics of a conditional coaX mutant that PanKBa is an essential enzyme, thus contributing to its validation as a new antimicrobial target.

* Corresponding author. Mailing address: Center for Structural Biology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157. Phone: (336) 716-3914. Fax: (336) 777-3242. E-mail: alc{at}csb.wfu.edu

{triangledown} Published ahead of print on 18 July 2008.

Journal of Bacteriology, September 2008, p. 6271-6275, Vol. 190, No. 18
0021-9193/08/$08.00+0     doi:10.1128/JB.00860-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»