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Journal of Bacteriology, October 2008, p. 6517-6523, Vol. 190, No. 19
0021-9193/08/$08.00+0     doi:10.1128/JB.00772-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

The CorA Mg2+ Channel Is Required for the Virulence of Salmonella enterica Serovar Typhimurium{triangledown} ,{dagger}

Krisztina M. Papp-Wallace,1* Margaret Nartea,3 David G. Kehres,1 Steffen Porwollik,2 Michael McClelland,2 Stephen J. Libby,3 Ferric C. Fang,3 and Michael E. Maguire1

Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106,1 Sidney Kimmel Cancer Center, San Diego, California 92121,2 Department of Laboratory Medicine, University of Washington, Seattle, Washington 981953

Received 30 May 2008/ Accepted 24 July 2008

CorA is the primary Mg2+ channel in Salmonella enterica serovar Typhimurium. A corA mutant is attenuated in mice and defective for invasion of and replication within epithelial cells. Microarray studies show that several virulence effectors are repressed in a corA mutant strain, which ultimately manifests itself as a decrease in virulence.

* Corresponding author. Mailing address: Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4965. Phone: (216) 368-6187. Fax: (216) 368-3395. E-mail: kmp12{at}po.cwru.edu

{triangledown} Published ahead of print on 1 August 2008.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, October 2008, p. 6517-6523, Vol. 190, No. 19
0021-9193/08/$08.00+0     doi:10.1128/JB.00772-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • O'Connor, K., Fletcher, S. A., Csonka, L. N. (2009). Increased expression of Mg2+ transport proteins enhances the survival of Salmonella enterica at high temperature. Proc. Natl. Acad. Sci. USA 106: 17522-17527 [Abstract] [Full Text]  
  • Webber, M. A., Bailey, A. M., Blair, J. M. A., Morgan, E., Stevens, M. P., Hinton, J. C. D., Ivens, A., Wain, J., Piddock, L. J. V. (2009). The Global Consequence of Disruption of the AcrAB-TolC Efflux Pump in Salmonella enterica Includes Reduced Expression of SPI-1 and Other Attributes Required To Infect the Host. J. Bacteriol. 191: 4276-4285 [Abstract] [Full Text]  
  • Moomaw, A. S., Maguire, M. E. (2008). The Unique Nature of Mg2+ Channels. Physiology 23: 275-285 [Abstract] [Full Text]  
  • Papp-Wallace, K. M., Maguire, M. E. (2008). Regulation of CorA Mg2+ Channel Function Affects the Virulence of Salmonella enterica Serovar Typhimurium. J. Bacteriol. 190: 6509-6516 [Abstract] [Full Text]  


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