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Journal of Bacteriology, October 2008, p. 6903-6908, Vol. 190, No. 20
0021-9193/08/$08.00+0     doi:10.1128/JB.00865-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Role of Phosphopantetheinyl Transferase Genes in Antibiotic Production by Streptomyces coelicolor{triangledown}

Ya-Wen Lu, Adrianna K. San Roman, and Amy M. Gehring*

Department of Chemistry, Williams College, Williamstown, Massachusetts 01267

Received 24 June 2008/ Accepted 1 August 2008

The phosphopantetheinyl transferase genes SCO5883 (redU) and SCO6673 were disrupted in Streptomyces coelicolor. The redU mutants did not synthesize undecylprodigiosin, while SCO6673 mutants failed to produce calcium-dependent antibiotic. Neither gene was essential for actinorhodin production or morphological development in S. coelicolor, although their mutation could influence these processes.

* Corresponding author. Mailing address: Department of Chemistry, Williams College, 47 Lab Campus Dr., Williamstown, MA 01267. Phone: (413) 597-3227. Fax: (413) 597-4116. E-mail: agehring{at}williams.edu

{triangledown} Published ahead of print on 8 August 2008.

Journal of Bacteriology, October 2008, p. 6903-6908, Vol. 190, No. 20
0021-9193/08/$08.00+0     doi:10.1128/JB.00865-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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