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 Previous Article

Journal of Bacteriology, December 2008, p. 7864-7867, Vol. 190, No. 23
0021-9193/08/$08.00+0     doi:10.1128/JB.01100-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Nitric Oxide and Oxygen Regulate Truncated Hemoglobin Gene Expression in Frankia Strain CcI3{triangledown} ,#

James Niemann{dagger} and Louis S. Tisa*

Department of Microbiology, University of New Hampshire, Durham, New Hampshire 03824-2617

Received 6 August 2008/ Accepted 16 September 2008

The Frankia genome contains two truncated hemoglobin genes (hboN and hboO) whose functions remain to be determined. Nitric oxide (NO) generated by the addition of 400 µM SNAP (S-nitroso-N-acetylpenicillamine) caused a 10-fold increase in hboN gene expression but had no effect on hboO expression. The addition of the NO scavenger, carboxy-PT10, reduced the effect of SNAP. hboO gene expression increased under low-oxygen conditions, while hboN expression was unaffected. These results suggest that HboN may function in protection from nitrosative stress and that HboO may act as an oxygen transport molecule for increased respiration in hypoxic environments.

* Corresponding author. Mailing address: Department of Microbiology, University of New Hampshire, 46 College Rd., Durham, NH 03824-2617. Phone: (603) 862-2442. Fax: (603) 862-2621. E-mail: louis.tisa{at}unh.edu

{triangledown} Published ahead of print on 26 September 2008.

# Scientific contribution 2367 from the New Hampshire Agricultural Experiment Station.

{dagger} Present address: Cell Signaling Technology, Danvers, MA 01923.

Journal of Bacteriology, December 2008, p. 7864-7867, Vol. 190, No. 23
0021-9193/08/$08.00+0     doi:10.1128/JB.01100-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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