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Journal of Bacteriology, May 2008, p. 3393-3398, Vol. 190, No. 9
0021-9193/08/$08.00+0     doi:10.1128/JB.01189-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Identification of Novel Genes and Pathways Affecting Salmonella Type III Secretion System 1 Using a Contact-Dependent Hemolysis Assay{triangledown}

Terry R. Field,{dagger} Abigail N. Layton,{dagger}* Jennie Bispham, Mark P. Stevens, and Edouard E. Galyov{ddagger}

Division of Microbiology, Institute for Animal Health, Compton, Berkshire, RG20 7NN, United Kingdom

Received 26 July 2007/ Accepted 17 February 2008

We screened 5,700 Salmonella enterica serovar Typhimurium mutants for defects in type III secretion system 1 (T3SS-1)-mediated contact-dependent hemolysis to identify novel genes and pathways affecting the activity of T3SS-1. Our data suggest that previously unrecognized factors such as type I fimbriae may modulate the expression, activity, or deployment of this key virulence factor.

* Corresponding author. Mailing address: Division of Microbiology, Institute for Animal Health, Compton, Berkshire, RG20 7NN, United Kingdom. Phone: 44 1635 578411. Fax: 44 1635 577237. E-mail: abigail.layton{at}bbsrc.ac.uk

{triangledown} Published ahead of print on 29 February 2008.

{dagger} T.R.F. and A.N.L. contributed equally to this work.

{ddagger} Present address: Department of Infection, Immunity, and Inflammation, Maurice Shock Building, University of Leicester, P.O. Box 138, Leicester LE1 9HN, United Kingdom.

Journal of Bacteriology, May 2008, p. 3393-3398, Vol. 190, No. 9
0021-9193/08/$08.00+0     doi:10.1128/JB.01189-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Stevens, M. P., Humphrey, T. J., Maskell, D. J. (2009). Molecular insights into farm animal and zoonotic Salmonella infections. Phil Trans R Soc B 364: 2709-2723 [Abstract] [Full Text]  


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