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Journal of Bacteriology, January 2009, p. 428-433, Vol. 191, No. 1
0021-9193/09/$08.00+0     doi:10.1128/JB.01234-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Transcriptome Divergence and the Loss of Plasticity in Bacillus subtilis after 6,000 Generations of Evolution under Relaxed Selection for Sporulation {triangledown} ,{dagger}

Heather Maughan,1* C. William Birky Jr.,1 and Wayne L. Nicholson2

Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721,1 Department of Microbiology and Cell Science, University of Florida, Space Life Sciences Laboratory, Kennedy Space Center, Florida 328992

Received 4 September 2008/ Accepted 16 October 2008

We used microarrays to identify the causes of sporulation deficiencies in Bacillus subtilis after 6,000 generations of evolution. We found that sporulation loss did not result from large-scale deletions; therefore, it must have resulted from smaller indels and/or substitutions. Transcription patterns of one strain versus its ancestor showed that sporulation was not initiated and suggested that sporulation loss may be part of an overall decline in plasticity.

* Corresponding author. Present address: Department of Zoology, University of British Columbia, Vancouver, British Columbia V5Y 2B3, Canada. Phone: (604) 822-6323. Fax: (604) 827-4135. E-mail: maughan{at}zoology.ubc.ca

{triangledown} Published ahead of print on 24 October 2008.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, January 2009, p. 428-433, Vol. 191, No. 1
0021-9193/09/$08.00+0     doi:10.1128/JB.01234-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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