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Journal of Bacteriology, June 2009, p. 3736-3739, Vol. 191, No. 11
0021-9193/09/$08.00+0     doi:10.1128/JB.00216-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

The Conserved Sporulation Protein YneE Inhibits DNA Replication in Bacillus subtilis{triangledown} ,{dagger}

Lilah Rahn-Lee,1 Boris Gorbatyuk,1 Ole Skovgaard,2 and Richard Losick1*

Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts,1 Department of Science, Systems and Models, Roskilde University, Roskilde, Denmark2

Received 18 February 2009/ Accepted 23 March 2009

Cells of Bacillus subtilis triggered to sporulate under conditions of rapid growth undergo a marked decrease in chromosome copy number, which was partially relieved by a mutation in the sporulation-induced gene yneE. Cells engineered to express yneE during growth were impaired in viability and produced anucleate cells. We conclude that YneE is an inhibitor of DNA replication.

* Corresponding author. Mailing address: Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Ave., Cambridge, MA 02138. Phone: (617) 495-4905. Fax: (617) 496-4642. E-mail: Losick{at}mcb.harvard.edu

{triangledown} Published ahead of print on 27 March 2009.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, June 2009, p. 3736-3739, Vol. 191, No. 11
0021-9193/09/$08.00+0     doi:10.1128/JB.00216-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Veening, J.-W., Murray, H., Errington, J. (2009). A mechanism for cell cycle regulation of sporulation initiation in Bacillus subtilis. Genes Dev. 23: 1959-1970 [Abstract] [Full Text]  
  • Ramamurthi, K. S., Losick, R. (2009). Negative membrane curvature as a cue for subcellular localization of a bacterial protein. Proc. Natl. Acad. Sci. USA 106: 13541-13545 [Abstract] [Full Text]  


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