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Journal of Bacteriology, June 2009, p. 4035-4040, Vol. 191, No. 12
0021-9193/09/$08.00+0     doi:10.1128/JB.00164-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Inhibition of Selenium Metabolism in the Oral Pathogen Treponema denticola{triangledown}

Sarah Jackson-Rosario and William T. Self*

Department of Molecular Biology and Microbiology, Burnett School of Biomedical Science, College of Medicine, University of Central Florida, Orlando, Florida

Received 6 February 2009/ Accepted 2 April 2009

In this report we provide evidence that the antimicrobial action of stannous salts and a gold drug, auranofin, against Treponema denticola is mediated through inhibition of the metabolism of selenium for synthesis of selenoproteins.

* Corresponding author. Mailing address: 4000 Central Florida Boulevard, Building 20, Room 124, Orlando, FL 32816-2364. Phone: (407) 823-4262. Fax: (407) 823-0956. E-mail: wself{at}mail.ucf.edu

{triangledown} Published ahead of print on 10 April 2009.

Journal of Bacteriology, June 2009, p. 4035-4040, Vol. 191, No. 12
0021-9193/09/$08.00+0     doi:10.1128/JB.00164-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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