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Journal of Bacteriology, June 2009, p. 4041-4043, Vol. 191, No. 12
0021-9193/09/$08.00+0     doi:10.1128/JB.00066-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

The Escherichia coli Mismatch Repair Protein MutL Recruits the Vsr and MutH Endonucleases in Response to DNA Damage{triangledown}

Yaroslava Y. Polosina, Justin Mui, Photini Pitsikas,{dagger} and Claire G. Cupples*

Department of Biochemistry and Microbiology, University of Victoria, P.O. Box 3055, STN CSC, Victoria, BC, Canada V8N 3P2

Received 17 January 2009/ Accepted 12 April 2009

The activities of the Vsr and MutH endonucleases of Escherichia coli are stimulated by MutL. The interaction of MutL with each enzyme is enhanced in vivo by 2-aminopurine treatment and by inactivation of the mutY gene. We hypothesize that MutL recruits the endonucleases to sites of DNA damage.

* Corresponding author. Mailing address: Department of Biochemistry and Microbiology, University of Victoria, P.O. Box 3055, STN CSC, Victoria, BC, Canada V8N 3P2. Phone: (250) 472-4458. Fax: (250) 721-8855. E-mail: ccupples{at}uvic.ca

{triangledown} Published ahead of print on 17 April 2009.

{dagger} Present address: Luminex Molecular Diagnostics, Toronto, ON, Canada.

Journal of Bacteriology, June 2009, p. 4041-4043, Vol. 191, No. 12
0021-9193/09/$08.00+0     doi:10.1128/JB.00066-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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